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Uhthoff's phenomenon : ウィキペディア英語版
Uhthoff's phenomenon
Uhthoff's phenomenon (also known as Uhthoff's syndrome, Uhthoff's sign, and Uhthoff's symptom) is the worsening of neurologic symptoms in multiple sclerosis (MS) and other neurological, demyelinating conditions when the body gets overheated from hot weather, exercise, fever, or saunas and hot tubs. It is possibly due to the effect of increased temperature on nerve conduction. With an increased body temperature, nerve impulses are either blocked or slowed down in a damaged nerve but once the body temperature is normalized, signs and symptoms may disappear or improve.
== History ==
This phenomenon was first described by Wilhelm Uhthoff in 1890〔W. Uhthoff: ''Untersuchungen über die bei der multiplen Herdsklerose vorkommenden Augenstörungen.'' Archiv für Psychiatrie und Nervenkrankheiten, Berlin, 1890, 21: 55-116 and 303-410.〕 as a temporary worsening of vision with exercise in patients with optic neuritis. Later research revealed the link between neurological signs such as visual loss and increased heat production and Uhthoff's belief that exercise was the etiology of visual loss was replaced by the conclusions of these later researchers stating that heat was the prime etiology.

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